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But not, the clear presence of ectopic calcification within the Achilles, patellar and quadriceps tendons was also stated in the biglycan and you will fibromodulin knockout mice 53. Another essential feature of SLRPs is the ability to regulate the newest hobby of one’s citizen telephone inhabitants by binding and sequestering gains issues 54, 55. The fresh distinction out of tendon progenitor tissues to your chondrocytes and you will bone tissue try modulated because of the expression out of biglycan and you can fibromodulin 56. It may be modulated because of the expression of biglycan and you may fibromodulin, and also by the word out of chondro-ostogenetic BMPs, such as BMP-dos, BMP-4 and you may BMP-7, that have been over-shown inside CT designs 57.

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